Graphical Abstract
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Yang et al. find that the histonemodification H3K27me3 accumulates inmany tissues with age, due to increasedtime in quiescence. H3K27me3 is gainedover lamin-associated domains butreduced at developmental genepromoters with consequent changes inglobal and local transcription. Liverregeneration breaks quiescence andpartially restores youthful patterns.
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We thank Dr. Payel Sen and her team for their guidance.
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